BASIS

The purpose of the “BASIS” trial is to compare two treatments for people with stress urinary incontinence (SUI). Stress urinary incontinence is the leakage of urine upon exertion, for example, when laughing, coughing, or lifting something heavy. The two treatments in this study are transurethral bulking agent (TBA) and single-incision sling (SIS). There is current evidence suggesting that TBA and SIS may be less effective at treating SUI, but these procedures are important to study because they are less invasive treatment options with fewer complications than traditional full-length mid-urethral sling procedures. These treatments are outpatient procedures that are commercially available and FDA-approved for patients with SUI, and have either no mesh material or less mesh material than traditional full-length mid-urethral sling procedures. The trial’s primary purpose is to evaluate how TBA and SIS compare to one another as treatments for SUI at one year after treatment.